What is MODY?
Maturity-Onset Diabetes of the Young (or MODY) is a term used to encompass a group of monogenic forms of diabetes. It accounts for about 1% of people with diabetes. Often patients are misdiagnosed as Type 1/ Type 2 Diabetes or Pre-diabetes. Distinguishing MODY from other forms of diabetes can be difficult for patients and clinicians. The distinguishing features are highlighted in each of the clinical scenarios.
The main features of MODY include:
• Diabetes often develops before the age of 30 years
• Diabetes often runs in families from one generation to the next
• Diabetes may be treated by diet or tablets and does not always need insulin treatment
The blood sugar problems seen in MODY are due to a single mutation or change within one of the MODY genes.
The common clinical scenarios are listed below – Click on each to learn more
I was initially diagnosed as Type 1 diabetes but I don’t fit the usual pattern
I was initially diagnosed as Type 2 diabetes but I don’t fit the usual pattern
My morning sugars are constantly mildly elevated
Some less common forms of MODY or genetic causes of diabetes are listed below – Click on each to learn more
Cystic Fibrosis Related Diabetes
MODY 4 (PDX1-MODY)
MODY 6 (NEUROD1-MODY)
MODY 10 (INS-MODY)