Mutations of the INS (insulin) gene can result in diabetes. The INS gene contains a blueprint for the insulin hormone. Disruption of this gene affects the normal function of insulin.
INS diabetes is typically diagnosed before 6 months of age and is often misdiagnosed as Type 1 diabetes mellitus. Rarely, diabetes will not develop until later in life, which can then be confused with MODY.
Unlike other forms of monogenic diabetes, oral medications do not correct the elevated blood sugars. Lifelong insulin shots or insulin pump therapy are required.
Finding an INS mutation in a patient’s family may have implications for other family members. An affected person’s child will each be at a 50% risk of inheriting the mutation and developing diabetes.
If you or a family member have an INS mutation or suspect yourself or a family member of having an INS mutation then please contact us to learn more about our studies.