Matt Brady, Research Feature

Matt Brady, PhD received his undergraduate and graduate degrees from University of Chicago.  After receiving his PhD in 1994, Brady moved to Ann Arbor, Michigan working for Park Davis. In 2001 Dr. Brady returned to University of Chicago and joined the Section of Adult and Pediatric Endocrinology, Diabetes and Metabolism as a faculty member, pursuing research in metabolic signaling.

Since his research began in 2001, Dr. Brady’s focus in the lab is metabolic signaling and understanding fat cells. Through the collaborative atmosphere at University of Chicago, Dr. Brady is now collaborating on two new cross-disciplinary projects.  The first research project centers around the effects of modulating sleep patterns on insulin sensitivity in human adipose (fat) tissue.  There have been an increasing number of studies that report a link between decreased sleep duration and/or quality and an increased risk for obesity and diabetes. In collaboration with Drs. Van Cauter, Ehrmann and Tasali in the Department of Medicine at the University of Chicago, they have initiated a series of studies to examine the effects of sleep disruption on insulin sensitivity in human cells.

The second project combines the research expertise of the oncology and endocrinology research teams, focusing on tumor progression in the mammary gland and investigating chronic isolation of breast cancer tumor growth in mice.  What is interesting is this indirectly looks at the link between diabetes and incidence of breast cancer.  By using this isolation model and superimpose high fat / carb diet to see if the two stressors impact growth.

“At Kovler, the open lab environment fosters cross-disciplinary research, helps researchers to think differently and use different techniques simply by the work happening in lab stations all around us.”  said Brady.  “I am very proud of the work we do and have enjoyed the unexpected direction my research has taken by teaming up with colleagues in other disciplines which will ultimately translate into simple concrete ways to improve Kovler’s patients health.”

Brady notes his metabolic research has evolved in the last 10 years and is excited where it will go in the future.  For a deeper look into the work of Dr. Brady and his colleagues at Kovler, visit