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Treatment for MODY

There are more than 10 described genetic causes of MODY.  Each course of treatment may be different, depending on the involved gene and other factors.

The most common form of MODY is due to mutations in the HNF1A gene.  It often can be treated with sulfonylurea pills – an oral medication that prompts the body to produce adequate levels of insulin on its own.

MODY due to mutations in the HNF4A gene is very similar to HNF1A-MODY and also can often be treated with sulfonylurea pills.

One form of MODY, caused by a change in the glucokinase gene (GCK gene), is usually so mild that no medications are needed.

It is unclear what the best treatment is for other types of MODY, and people with MODY may require multiple daily injections of insulin to have good diabetes control.

If you or a loved one has MODY, it is critical to stay under the care of a specialist. He or she will work with you to determine the most appropriate course of treatment.