INS

Mutations of the INS (insulin) gene can result in diabetes. The INS gene contains a blueprint for the insulin hormone. Disruption of this gene affects the normal function of insulin.

Presentation:

INS diabetes is typically diagnosed before 6 months of age and is often misdiagnosed as Type 1 diabetes mellitus. Rarely, diabetes will not develop until later in life, which can then be confused with MODY.

Treatment:

Unlike other forms of monogenic diabetes, oral medications do not correct the elevated blood sugars. Lifelong insulin shots or insulin pump therapy are required.

Inheritance:

Finding an INS mutation in a patient’s family may have implications for other family members. An affected person’s child will each be at a 50% risk of inheriting the mutation and developing diabetes.

Research:

If you or a family member have an INS mutation or suspect yourself or a family member of having an INS mutation then please contact us to learn more about our studies.